General Information

  • ID:  hor005594
  • Uniprot ID:  O42241
  • Protein name:  GnRH-associated peptide 2
  • Gene name:  gnrh2
  • Organism:  Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  ELDSFTTSEISEGIKLCEAEGCSYLRPQRRNILKNVILDALAREFQKRK
  • Length:  49(38-86)
  • Propeptide:  MVSVARLVFMLGPLLCLGAQLSSSQHWSHGWYPGGKRELDSFTTSEISEGIKLCEAEGCSYLRPQRRNILKNVILDALAREFQKRK
  • Signal peptide:  MVSVARLVFMLGPLLCLGAQLSSS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A1Z0M0-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor005594_AF2.pdbhor005594_ESM.pdb

Physical Information

Mass: 652685 Formula: C246H408N72O77S2
Absent amino acids: HMW Common amino acids: EL
pI: 8.22 Basic residues: 9
Polar residues: 13 Hydrophobic residues: 16
Hydrophobicity: -55.92 Boman Index: -12927
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 91.63
Instability Index: 6806.94 Extinction Coefficient cystines: 1615
Absorbance 280nm: 33.65

Literature

  • PubMed ID:  NA
  • Title:  NA